Issue 2, 2020

A soft X-ray activated lanthanide scintillator for controllable NO release and gas-sensitized cancer therapy

Abstract

Multifunctional light stimuli-responsive NO-based gaseous theranostic systems are highly desirable due to them directly killing cancer cells at high concentration (>1 μM) with minimized adverse effects. However, on-demand NO-releasing nano-platforms for deep-tissue gas-based cancer therapy have not yet been explored. Herein, we develop a new type of soft X-ray-activated NaYF4:Gd/Tb scintillator as a light transducer for depth-independent NO release and on-demand gas-sensitized cancer therapy. Benefiting from the excellent radioluminescent property of NaYF4:Gd/Tb, deep-tissue (up to 3 cm) NO release can be achieved by ultralow dosage soft X-ray (45 kVp, 0.18–0.85 mGy) irradiation. More importantly, the designed scintillator-based NO gasotransmitter presents significant inhibition of tumor growth under ultralow dosage soft X-ray irradiation. Therefore, such a soft X-ray activated NO-releasing nanoplatform provides a promising depth-independent gaseous therapy mode for defeating deep-seated cancer in the future.

Graphical abstract: A soft X-ray activated lanthanide scintillator for controllable NO release and gas-sensitized cancer therapy

Supplementary files

Article information

Article type
Communication
Submitted
26 Aug 2019
Accepted
09 Sep 2019
First published
09 Sep 2019

Nanoscale Horiz., 2020,5, 268-273

A soft X-ray activated lanthanide scintillator for controllable NO release and gas-sensitized cancer therapy

M. Jiang, Z. Xue, Y. Li, H. Liu, S. Zeng and J. Hao, Nanoscale Horiz., 2020, 5, 268 DOI: 10.1039/C9NH00564A

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