Issue 35, 2020

Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells

Abstract

A hybrid gene delivery platform, micro Cell Vesicle Technology (mCVT), produced from the fusion of plasma membranes and cationic lipids, is presently used to improve the transfection efficiency of hard-to-transfect (HTT) cells. The plasma membrane components of mCVTs impart specificity in cellular uptake and reduce cytotoxicity in the transfection process, while the cationic lipids complex with the genetic material and provide structural integrity to mCVTs.

Graphical abstract: Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells

Supplementary files

Article information

Article type
Communication
Submitted
15 May 2020
Accepted
17 Aug 2020
First published
18 Aug 2020

Nanoscale, 2020,12, 18022-18030

Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells

Y. Ou, S. Zou, W. J. Goh, S. Y. Chong, G. Venkatesan, M. G. Wacker, G. Storm, J. Wang, B. Czarny, G. Pastorin and E. C. Y. Woon, Nanoscale, 2020, 12, 18022 DOI: 10.1039/D0NR03784B

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