Synthesis of α-CF3-substituted E-dehydroornithine derivatives via copper(i)-catalyzed hydroamination of allenes†
Florian
Monnier 
bc
and
Sergey N.
Osipov
*a
bc
and
Sergey N.
Osipov
*a
Abstract
An efficient synthetic approach to novel α-CF3-substituted E-dehydroornithine derivatives and their phosphorus analogues has been developed via the Cu(I)-catalyzed hydroamination of trifluoromethyl-containing α-allenyl-α-aminocarboxylates and α-allenyl-α-aminophosphonates with primary and secondary amines.
- This article is part of the themed collection: Synthetic methodology in OBC
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