Trifunctionalization of alkenes and alkynes

Abstract

Trifunctionalization is a versatile procedure to enable complex and diverse chemical compounds by constructing three functional groups concurrently in one step from simple and readily available feedstock reagents. The development of new trifunctionalization methods is a growing realm, with a significant impact on synthetic organic chemistry in recent times. Several trifunctionalization methodologies have been disclosed for different organic systems in the last two decades. This review presents the development of trifunctionalization methods for alkenes and alkynes, including arynes and allenes, published so far.