Xuxue Zhang, Chuan Liu, Yupian Deng and Song Cao
Org. Biomol. Chem., 2020,18, 7540-7544
DOI:
10.1039/D0OB01821J,
Communication
A facile and practical method for the synthesis of 2,3,4-trisubstituted 2-aminothiophenes by the cyclization of gem-dibromoalkenes or gem-dichloroalkenes with β-keto tertiary thioamides has been developed. The cyclization reaction proceeded chemoselectively and regioselectively under metal-catalyst-free conditions, providing various structurally diverse 2,3,4-trisubstituted N,N′-dialkyl 2-aminothiophenes in good to excellent yields.