Palladium(ii)-catalyzed tandem cyclization of 2-ethynylaniline tethered cinnamyl acetate for the synthesis of indenoindoles

Abstract

A palladium(II)-catalyzed cyclization of 2-ethynylaniline tethered cinnamyl acetate involving aminopalladation/alkene insertion/β-acetoxy elimination cascade processes was established. The new protocol provides efficient access to indenoindoles in moderate to good yields under mild conditions.