Issue 1, 2020

Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles

Abstract

We demonstrate amyloid fibril (AF) decomposition induced by NIR-active upconversion nanoparticles complexed with photosensitisers. The process is triggered by upconversion, which initiates a photochemical reaction cascade that culminates in the generation of the highly reactive singlet-oxygen product 1O2 close to the amyloid superstructures, resulting in AF decomposition.

Graphical abstract: Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
28 Aug 2019
Accepted
06 Jan 2020
First published
14 Jan 2020

Photochem. Photobiol. Sci., 2020,19, 29-33

Author version available

Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles

T. Harada, H. Matsuzaki, R. Oyama, T. Takeuchi, T. Takei, T. Ninomiya, K. Takami, T. Inoue, H. Nishiguchi, E. Hifumi, H. Shinto, H. Takahashi and K. Umemura, Photochem. Photobiol. Sci., 2020, 19, 29 DOI: 10.1039/C9PP00356H

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