Transition-metal free direct C–H functionalization of quinoxalin-2(1H)-ones with oxamic acids leading to 3-carbamoyl quinoxalin-2(1H)-ones

Abstract

A practical transition-metal free decarboxylative coupling reaction of oxamic acids with quinoxalin-2(1H)-ones has been developed under mild conditions. This transformation provides an efficient approach for the preparation of 3-carbamoyl quinoxalin-2(1H)-ones, which are important subunits in biologically active natural products and medicinal chemistry. This protocol features broad substrate scope, good yields, and mild reaction conditions.