Palladium-catalyzed ortho-selective C–H hydroxylation of carboxybenzyl-protected benzylamines

Abstract

A convenient approach to synthesize o-hydroxybenzylamine via Pd-catalyzed hydroxylation of benzylamine with a removable Cbz-amide as the directing group was developed. Various functional groups were well tolerated, leading to various substituted o-hydroxybenzylamines in moderate to good yields.