Roquefornine A, a sesterterpenoid with a 5/6/5/5/6-fused ring system from the fungus Penicillium roqueforti YJ-14

Jia-Peng Wang; Yan Shu; Jun-Tao Hu; Rui Liu; Xue-Yun Cai; Cheng-Tong Sun; Dong Gan; Di-Jiao Zhou; Rui-Feng Mei; Hao Ding; Xiao-Ran Zhang; Le Cai; Zhong-Tao Ding

doi:10.1039/D0QO00301H

Roquefornine A, a sesterterpenoid with a 5/6/5/5/6-fused ring system from the fungus Penicillium roqueforti YJ-14†

Jia-Peng Wang,

‡^a Yan Shu,‡^a Jun-Tao Hu,^a Rui Liu,^a Xue-Yun Cai,^a Cheng-Tong Sun,^a Dong Gan,^a Di-Jiao Zhou,^a Rui-Feng Mei,^a Hao Ding,^a Xiao-Ran Zhang,^a Le Cai*^a and Zhong-Tao Ding

*^a

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* Corresponding authors

^a Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P.R. China
E-mail: ztding@ynu.edu.cn, caile@ynu.edu.cn

Abstract

Roquefornine A, a sesterterpenoid with an unprecedented 5/6/5/5/6-membered pentacyclic system, was characterized from Penicillium roqueforti YJ-14. Its structure was determined by extensive spectroscopic analyses, [Rh₂(OCOCF₃)₄]-induced CD data, and DP4+ calculations. A biosynthetic pathway, cytotoxicity, and anti-inflammatory activity were also discussed.

Organic Chemistry Frontiers

Roquefornine A, a sesterterpenoid with a 5/6/5/5/6-fused ring system from the fungus Penicillium roqueforti YJ-14†

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Roquefornine A, a sesterterpenoid with a 5/6/5/5/6-fused ring system from the fungus Penicillium roqueforti YJ-14

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