Copper-catalyzed asymmetric tandem borylative addition and aldol cyclization

Abstract

A highly enantioselective asymmetric copper-catalyzed tandem conjugate addition/aldol cyclization of electron-deficient olefins with B₂pin₂ was developed, which provided a rapid access to multi-substituted indanes bearing three consecutive chiral stereogenic centers at the same side of the indane ring. The features of this reaction include high chemo-, diastereo- and enantio-selectivity (up to 99% ee) and mild reaction conditions.