AIBN for Ru-catalyzed meta-CAr–H alkylation

Suling Yang; Bingxu Yan; Lei Zhong; Chunqi Jia; Dan Yao; Chunli Yang; Kai Sun; Gang Li

doi:10.1039/D0QO00703J

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AIBN for Ru-catalyzed meta-C_Ar–H alkylation†

Suling Yang,

^a Bingxu Yan,^a Lei Zhong,^a Chunqi Jia,^b Dan Yao,^a Chunli Yang,^a Kai Sun^a and Gang Li

*^a

Author affiliations

* Corresponding authors

^a College of Chemistry and Chemical Engineering, Henan Province Key Laboratory of New Optoelectronic Functional Materials, Anyang Normal University, Anyang 455002, PR China
E-mail: ligang@aynu.edu.cn

^b Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, PR China

Abstract

The meta-C_Ar–H alkylation of arenes with radicals produced from AIBN in the presence of a RuCl₃ catalyst is presented. This development not only confirmed that ruthenium-catalyzed meta-C_Ar–H bond functionalization is a radical process, but also provided an efficient and practical strategy for the preparation of aromatic compounds containing a nitrile group, which are prevalent in a diverse range of biologically active molecules and other functional materials.

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Article information

DOI: https://doi.org/10.1039/D0QO00703J
Article type: Research Article
Submitted: 17 Jun 2020
Accepted: 21 Jul 2020
First published: 23 Jul 2020

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Org. Chem. Front., 2020,7, 2474-2479

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AIBN for Ru-catalyzed meta-C_Ar–H alkylation

S. Yang, B. Yan, L. Zhong, C. Jia, D. Yao, C. Yang, K. Sun and G. Li, Org. Chem. Front., 2020, 7, 2474 DOI: 10.1039/D0QO00703J

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