Issue 18, 2020

Transition metal-free synthesis of 3-trifluoromethyl chromones via tandem C–H trifluoromethylation and chromone annulation of enaminones

Abstract

The tandem C–H bond trifluoromethylation and chromone annulation reactions of o-hydroxyphenyl enaminones have been realized for the practical synthesis of 3-trifluoromethyl chromones. The reactions are performed efficiently with the promotion of K2S2O8 without using any transition metal catalyst or additive. In addition, the 3-trifluoromethyl chromone products have been successfully used for the synthesis of 3-trifluoromethyl pyrimidines by reacting with guanidine/amidine substrates.

Graphical abstract: Transition metal-free synthesis of 3-trifluoromethyl chromones via tandem C–H trifluoromethylation and chromone annulation of enaminones

Supplementary files

Article information

Article type
Research Article
Submitted
18 Jul 2020
Accepted
22 Aug 2020
First published
24 Aug 2020

Org. Chem. Front., 2020,7, 2770-2775

Transition metal-free synthesis of 3-trifluoromethyl chromones via tandem C–H trifluoromethylation and chromone annulation of enaminones

Q. Yu, Y. Liu and J. Wan, Org. Chem. Front., 2020, 7, 2770 DOI: 10.1039/D0QO00855A

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