Issue 20, 2020
From the journal:

Organic Chemistry Frontiers

Pd/NBE-catalyzed sequential carbamoylation/olefination of aryl iodides†

Chen Chen, ORCID logo *a   Liying Liu,a   Wan Sun,a   Jie Ding,a   Yan-Ping Zhub  and  Bolin Zhu ORCID logo *a  

* Corresponding authors

a Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, P. R. China
E-mail: hxxycc@tjnu.edu.cn, hxxyzbl@tjnu.edu.cn

b School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Shandong, Yantai, P. R. China

Abstract

We report a palladium/norbornene cooperative catalyzed ortho-carbamoylation/ipso-Heck cyclization of aryl iodides using alkene-tethered carbamoyl chlorides. This reaction was carried out using readily available starting materials under mild reaction conditions, and a variety of 4-methylene-3,4-dihydro-1(2H)-isoquinolin-1-one analogues were obtained in moderate to good yields.

Graphical abstract: Pd/NBE-catalyzed sequential carbamoylation/olefination of aryl iodides

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0QO00905A
Article type
Research Article
Submitted
27 Jul 2020
Accepted
04 Sep 2020
First published
07 Sep 2020

Org. Chem. Front., 2020,7, 3179-3185

Permissions

Request permissions

Pd/NBE-catalyzed sequential carbamoylation/olefination of aryl iodides

C. Chen, L. Liu, W. Sun, J. Ding, Y. Zhu and B. Zhu, Org. Chem. Front., 2020, 7, 3179 DOI: 10.1039/D0QO00905A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements