Issue 7, 2020, Issue in Progress
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RSC Advances

Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin

Bengi Ozkahraman,ad   Krisztina Emeriewen,b   George M. Salehbc  and  Nguyen Thi Kim Thanh ORCID logo *de  

* Corresponding authors

a Hitit University, Faculty of Engineering, Polymer Engineering Department, Corum, Turkey

b Moorfields Eye Hospital NHS Foundation Trust, London, UK

c The National Insitute for Health Research Biomedical Research Centre at Moorfields Eye Hospital, UCL Institute of Opthalmology, 11-43 Bath St, London EC1V 9EL, UK

d Biophysics Group, Department of Physics and Astronomy, University College London, Gower Street, London, UK
E-mail: ntk.thanh@ucl.ac.uk

e UCL Healthcare Biomagnetic and Nanomaterials Laboratories, University College London, 21 Albemarle Street, London W1S 4BS, UK

Abstract

Herein, we focused on developing the feasibility of nano-enabled local anaesthetic (LA) delivery to anaesthetise the full thickness of eyelid skin. For this purpose a temperature-responsive hydrogel poly(N-vinylcaprolactam-co-hyaluronic acid) (p(VCL-co-HA)) was prepared through aqueous emulsion polymerization with a Food and Drug Administration (FDA) approved p(VCL) and hyaluronic acid (HA) showing remarkably high LA drug loading capacity.

Graphical abstract: Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin

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Article information

DOI
https://doi.org/10.1039/C9RA06712D
Article type
Paper
Submitted
25 Aug 2019
Accepted
09 Dec 2019
First published
23 Jan 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 3926-3930

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Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin

B. Ozkahraman, K. Emeriewen, G. M. Saleh and N. T. K. Thanh, RSC Adv., 2020, 10, 3926 DOI: 10.1039/C9RA06712D

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