Issue 5, 2020, Issue in Progress
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RSC Advances

Synergic effect of doxorubicin release and two-photon irradiation of Mn2+-doped Prussian blue nanoparticles on cancer therapy†

Lamiaa M. A. Ali,‡ab   Emna Mathlouthi,‡cd   Maëlle Cahu,c   Saad Sene,c   Morgane Daurat,ae   Jérôme Long, ORCID logo c   Yannick Guari, ORCID logo c   Fabrice Salles,c   Joël Chopineau, ORCID logo c   Jean-Marie Devoisselle, ORCID logo c   Joulia Larionova ORCID logo *c  and  Magali Gary-Bobo*a  

* Corresponding authors

a Institut des Biomolécules Max Mousseron, UMR5247, Université de Montpellier, CNRS, ENSCM, Faculté de Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 05, France
E-mail: magali.gary-bobo@inserm.fr

b Department of Biochemistry, Medical Research Institute, University of Alexandria, Alexandria, Egypt

c Institut Charles Gerhardt, Université de Montpellier, CNRS, ENSCM, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France
E-mail: joulia.larionova@umontpellier.fr

d Université de Tunis el Manar, Faculté des Sciences, UR/11/ES/19, Physico-chimie des matériaux à l'état condensé, Tunis, Tunisia

e NanoMedSyn, 15 Avenue Charles Flahault, 34093 Montpellier, France

Abstract

We demonstrate here that Mn2+-doped Prussian blue nanoparticles of ca. 55 nm loaded with doxorubicin may be used as efficient therapeutic agents for combined photothermal and chemo-therapy of cancer cells with a synergic effect under two photon irradiation.

Graphical abstract: Synergic effect of doxorubicin release and two-photon irradiation of Mn2+-doped Prussian blue nanoparticles on cancer therapy

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Article information

DOI
https://doi.org/10.1039/C9RA09133E
Article type
Paper
Submitted
04 Nov 2019
Accepted
02 Jan 2020
First published
15 Jan 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 2646-2649

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Synergic effect of doxorubicin release and two-photon irradiation of Mn2+-doped Prussian blue nanoparticles on cancer therapy

L. M. A. Ali, E. Mathlouthi, M. Cahu, S. Sene, M. Daurat, J. Long, Y. Guari, F. Salles, J. Chopineau, J. Devoisselle, J. Larionova and M. Gary-Bobo, RSC Adv., 2020, 10, 2646 DOI: 10.1039/C9RA09133E

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