Rigor and reproducibility in polymer nanoparticle synthesis and characterization

Kenneth R. Sims; Julian P. Maceren; Alexander Ian Strand; Brian He; Clyde Overby; Danielle S. W. Benoit

doi:10.1039/C9RA10091A

Rigor and reproducibility in polymer nanoparticle synthesis and characterization†

Kenneth R. Sims, Jr,^ab Julian P. Maceren,^c Alexander Ian Strand,^a Brian He,^d Clyde Overby

^a and Danielle S. W. Benoit

*^aefgh

Author affiliations

* Corresponding authors

^a Dept. of Biomedical Engineering, University of Rochester, Rochester, NY, USA
E-mail: benoit@bme.rochester.edu

^b Translational Biomedical Science, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

^c Dept. of Chemistry, University of Rochester, Rochester, NY, USA

^d Dept. of Statistics, University of Rochester, Rochester, NY, USA

^e Materials Science Program, Rochester, NY, USA

^f Center for Oral Biology, University of Rochester, Rochester, NY, USA

^g Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA

^h Dept. of Chemical Engineering, University of Rochester, Rochester, NY, USA

Abstract

Standardized process improvement methods and tools were used to enhance the rigor and reproducibility of diblock copolymer nanoparticle (NP) synthesis and characterization. Models linking design parameters with NP characteristics boosted process control for NP synthesis, which may improve translation and commercialization of NP research.

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DOI: https://doi.org/10.1039/C9RA10091A
Article type: Paper
Submitted: 02 Dec 2019
Accepted: 07 Jan 2020
First published: 14 Jan 2020
This article is Open Access

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RSC Adv., 2020,10, 2513-2518

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Rigor and reproducibility in polymer nanoparticle synthesis and characterization

K. R. Sims, J. P. Maceren, A. I. Strand, B. He, C. Overby and D. S. W. Benoit, RSC Adv., 2020, 10, 2513 DOI: 10.1039/C9RA10091A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Rigor and reproducibility in polymer nanoparticle synthesis and characterization†

Abstract

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Article information

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Rigor and reproducibility in polymer nanoparticle synthesis and characterization

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