Issue 4, 2020, Issue in Progress

Diagnostically analyzing 1H NMR spectra of sub-types in chaetoglobosins for dereplication

Abstract

1 H-NMR spectra provide abundant diagnostic information including chemical shift values, splitting patterns, coupling constants, and integrals. Thus some key functional groups, and even planar structures could be elucidated on the basis of carefully analyzing the corresponding 1H NMR spectrum. In this paper, the different sub-types of chaetoglobosins are classified according to the structural features, of which the 1H NMR spectra are systematically summed up. Thus diagnostically analyzing the 1H-NMR spectra could identify possible sub-types of chaetoglobosins, which could be used for dereplication. According to the analysis of this report, it implies that different new sub-types or new sub-type combinations in the key skeleton of chaetoglobosins might exist in nature. More importantly, dereplication based on 1H NMR spectral analysis will not only provide a useful approach to determine the chaetoglobosins structures quickly, but also could set a good example for structural dereplication of other NPs.

Graphical abstract: Diagnostically analyzing 1H NMR spectra of sub-types in chaetoglobosins for dereplication

Supplementary files

Article information

Article type
Paper
Submitted
12 Dec 2019
Accepted
30 Dec 2019
First published
09 Jan 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 1946-1955

Diagnostically analyzing 1H NMR spectra of sub-types in chaetoglobosins for dereplication

C. Lin, J. Qin, Y. Zhang and G. Ding, RSC Adv., 2020, 10, 1946 DOI: 10.1039/C9RA10434H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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