Issue 43, 2020, Issue in Progress
From the journal:

RSC Advances

Silver-catalyzed regioselective deuteration of (hetero)arenes and α-deuteration of 2-alkyl azaarenes†

Baobiao Dong,ab   Xuefeng Cong ORCID logo *b  and  Na Hao*a  

* Corresponding authors

a Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou 646000, China
E-mail: haona@swmu.edu.cn

b Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, China
E-mail: congxf010@nenu.edu.cn

Abstract

A simple silver-catalyzed regioselective deuteration of (hetero)arenes and α-deuteration of 2-alkyl azaarenes has been described. This strategy provides an efficient and practical avenue to access various deuterated electron-rich arenes, azaarenes and α-deuterated 2-alkyl azaarenes with good to excellent deuterium incorporation utilizing D2O as the source of deuterium atoms.

Graphical abstract: Silver-catalyzed regioselective deuteration of (hetero)arenes and α-deuteration of 2-alkyl azaarenes

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Article information

DOI
https://doi.org/10.1039/D0RA02358B
Article type
Paper
Submitted
13 Mar 2020
Accepted
28 Jun 2020
First published
06 Jul 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 25475-25479

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Silver-catalyzed regioselective deuteration of (hetero)arenes and α-deuteration of 2-alkyl azaarenes

B. Dong, X. Cong and N. Hao, RSC Adv., 2020, 10, 25475 DOI: 10.1039/D0RA02358B

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