Issue 30, 2020, Issue in Progress
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RSC Advances

Chlorotrifluoroethylidenes: an efficient and convenient approach to their synthesis†

Abhay Atmaram Upare,ab   Pradip K. Gadekar,b   Kiran Jadhav,b   H. Sivaramakrishnanb  and  Selvaraj Mohana Roopan ORCID logo *a  

* Corresponding authors

a Chemistry of Heterocycles and Natural Product Research Lab, Department of Chemistry, School of Advanced Science, Vellore Institute of Technology, Vellore – 632014, Tamil Nadu, India
E-mail: mohanaroopan.s@vit.ac.in
Tel: +91-0416-220-2313

b Department of Process Development, Piramal Enterprises Ltd., Lighthall A Wing, Hiranandani Business Park, Sakivihar Road, Chandivali, Andheri (East), Mumbai 400072, India

Abstract

A convenient one step synthesis of chlorotrifluoroalkyl olefins starting from aldehydes was developed. The stable reagent 2-((1-chloro-2,2,2-trifluoroethyl)sulfonyl)benzothiazole was prepared from readily available benzothiazole-2-thiol and halothane. This method comprises using stable 2-((1-chloro-2,2,2-trifluoroethyl)sulfonyl)benzothiazole according to the Julia procedure and presents new opportunities for the synthesis of trifluoroalkylidene derivatives.

Graphical abstract: Chlorotrifluoroethylidenes: an efficient and convenient approach to their synthesis

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Article information

DOI
https://doi.org/10.1039/D0RA02481C
Article type
Paper
Submitted
17 Mar 2020
Accepted
15 Apr 2020
First published
05 May 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 17427-17431

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Chlorotrifluoroethylidenes: an efficient and convenient approach to their synthesis

A. A. Upare, P. K. Gadekar, K. Jadhav, H. Sivaramakrishnan and S. M. Roopan, RSC Adv., 2020, 10, 17427 DOI: 10.1039/D0RA02481C

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