Issue 55, 2020, Issue in Progress

Carbon fibers for treatment of cancer metastasis in bone

Abstract

When cancer metastasizes to bone, the resulting pain and functional disorders due to bone destruction adversely affect the patient's quality of life. We have developed a new cancer metastasis control system consisting of anticancer agents conjugated to carbon fibers (CFs), which are nonbiodegradable, carriers of a wide variety of molecules with extremely high affinity for bone. In the evaluation of cancer suppression effects on Walker 256 cancer cells, cisplatin (CDDP)-conjugated CFs (CF-CDDP) were found to be as effective in cancer suppression as CDDP. In the evaluation of the cancer suppression effects of local injection in the rat model of tibial cancer bone metastasis, similar cancer suppression was noted in the CF-CDDP group and CDDP group; however, blood Pt concentrations were significantly lower in the CF-CDDP group. Experiments with CDDP and CF-CDDP injected into bone actually destroyed by cancer metastases revealed the presence of significantly more newly formed bone tissue with the administration of CF-CDDP. Local administration of CF-CDDP is expected to become the first therapy to suppress cancer growth with low prevalence of adverse reactions, and to repair bone damaged by metastasis.

Graphical abstract: Carbon fibers for treatment of cancer metastasis in bone

Article information

Article type
Paper
Submitted
27 May 2020
Accepted
28 Aug 2020
First published
07 Sep 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 33071-33079

Carbon fibers for treatment of cancer metastasis in bone

T. Kamanaka, H. Haniu, M. Tanaka, T. Takizawa, K. Aoki, M. Okamoto, A. Sobajima, K. Yoshida, H. Ideta, T. Mimura, H. Ishida, K. Ueda, T. Uemura, J. H. Kim, Y. A. Kim, H. Kato and N. Saito, RSC Adv., 2020, 10, 33071 DOI: 10.1039/D0RA05992G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements