Issue 67, 2020, Issue in Progress
From the journal:

RSC Advances

Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR†

Sivaranjan Uppala,a   Ayelet Gamliel,a   Gal Sapir, ORCID logo a   Jacob Sosna,a   J. Moshe Gomoria  and  Rachel Katz-Brull ORCID logo *a  

* Corresponding authors

a Department of Radiology, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine, Jerusalem, Israel
E-mail: rkb@hadassah.org.il

Abstract

A hyperpolarised-NMR acquisition approach that is sensitive to the process of glucose-6-phosphate anomerization is presented. Using selective depolarisation of one of the anomer's signals, it is possible to observe the replenishing of this signal due to the fast anomeric exchange of this compound. The forward to reverse reaction rate constants ratio was ca. 1.6.

Graphical abstract: Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR

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Article information

DOI
https://doi.org/10.1039/D0RA08022E
Article type
Paper
Submitted
19 Sep 2020
Accepted
23 Oct 2020
First published
11 Nov 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 41197-41201

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Observation of glucose-6-phosphate anomeric exchange in real-time using dDNP hyperpolarised NMR

S. Uppala, A. Gamliel, G. Sapir, J. Sosna, J. M. Gomori and R. Katz-Brull, RSC Adv., 2020, 10, 41197 DOI: 10.1039/D0RA08022E

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