Issue 47, 2020

Palladium-catalyzed direct asymmetric C–H bond functionalization enabled by the directing group strategy

Abstract

In the past decade, selective C–C and C-heteroatom bond construction through palladium-catalyzed direct C–H bond functionalization has been extensively studied by employing a variety of directing groups. Within this category, direct asymmetric C(sp2)–H and C(sp3)–H activation for the construction of highly enantiomerically enriched skeletons still progressed at a slow pace. This minireview briefly introduces the major advances in the field for palladium-catalyzed direct asymmetric C–H bond functionalization via the directing group strategy.

Graphical abstract: Palladium-catalyzed direct asymmetric C–H bond functionalization enabled by the directing group strategy

Article information

Article type
Minireview
Submitted
31 May 2020
Accepted
08 Jul 2020
First published
09 Jul 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 12616-12632

Palladium-catalyzed direct asymmetric C–H bond functionalization enabled by the directing group strategy

K. Yang, M. Song, H. Liu and H. Ge, Chem. Sci., 2020, 11, 12616 DOI: 10.1039/D0SC03052J

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