Issue 35, 2020

Controlling the degradation of cellulose scaffolds with Malaprade oxidation for tissue engineering

Abstract

This study was conducted to develop biodegradable cellulose scaffolds by oxidising porous cellulose sponges for tissue engineering applications. Cellulose powder was dissolved in ionic liquid using a salt leaching method, and porous cellulose scaffolds of various pore sizes were prepared. The scaffolds were oxidised with periodate to introduce aldehyde at a rate controlled by the periodate concentration. Oxidised scaffolds exhibited weight loss in cell culture medium, but not in phosphate buffer. Therefore, we confirmed that Schiff base formation between the aldehyde and amino groups through a Maillard reaction triggered cellulose molecular degradation. The degradation rate was controlled by the oxidation degree, whereas the aldehyde content controlled protein adsorption and cell proliferation. Additionally, in vivo implantation tests revealed that optimising the oxidation ratio not only improved biodegradability but also reduced inflammation. In conclusion, our results suggest that simple oxidised cellulose is useful as a low-toxicity biodegradable scaffold.

Graphical abstract: Controlling the degradation of cellulose scaffolds with Malaprade oxidation for tissue engineering

Supplementary files

Article information

Article type
Paper
Submitted
19 Apr 2020
Accepted
13 Aug 2020
First published
13 Aug 2020

J. Mater. Chem. B, 2020,8, 7904-7913

Controlling the degradation of cellulose scaffolds with Malaprade oxidation for tissue engineering

W. Chimpibul, T. Nakaji-Hirabayashi, X. Yuan and K. Matsumura, J. Mater. Chem. B, 2020, 8, 7904 DOI: 10.1039/D0TB01015D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements