How does DNA ‘meet’ capillary-based microsystems?

Abstract

DNA possesses various chemical and physical properties which make it important in biological analysis. The opportunity for DNA to ‘meet’ capillary-based microsystems is rapidly increasing owing to the expanding development of miniaturization. Novel capillary-based methods can provide favourable platforms for DNA–ligand interaction assay, DNA translocation study, DNA separation, DNA aptamer selection, DNA amplification assay, and DNA digestion. Meanwhile, DNA exhibits great potential in the fabrication of new capillary-based biosensors and enzymatic bioreactors. Moreover, DNA has received significant research interest in improving capillary electrophoresis (CE) performance. We focus on highlighting the advantages of combining DNA and capillary-based microsystems. The general trend presented in this review suggests that the ‘meeting’ has offered a stepping stone for the application of DNA and capillary-based microsystems in the field of analytical chemistry.