Issue 24, 2021
From the journal:

Analyst

On-demand nanozyme signal enhancement at the push of a button for the improved detection of SARS-CoV-2 nucleocapsid protein in serum

Daniel W. Bradbury, ORCID logo a   Jasmine T. Trinh,a   Milo J. Ryan,a   Cassandra M. Cantu,a   Jiakun Lu,a   Frances D. Nicklen,a   Yushen Du,bc   Ren Sun,bd   Benjamin M. Wuae  and  Daniel T. Kamei ORCID logo *a  

* Corresponding authors

a Department of Bioengineering, University of California, Los Angeles, CA 90095, USA
E-mail: kamei@seas.ucla.edu

b Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA

c ZJU-UCLA Joint Center for Medical Education and Research, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China

d School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China

e Division of Advanced Prosthodontics & Weintraub Center for Reconstructive Biotechnology School of Dentistry, University of California, Los Angeles, CA 90095, USA

Abstract

We developed an innovative 3D printed casing that incorporates a lateral-flow immunoassay, dehydrated signal enhancement reagents, and a sealed buffer chamber. With only the push of a button for signal enhancement, our device detected the SARS-CoV-2 N-protein in 40 min at concentrations as low as 0.1 ng mL−1 in undiluted serum.

Graphical abstract: On-demand nanozyme signal enhancement at the push of a button for the improved detection of SARS-CoV-2 nucleocapsid protein in serum

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Article information

DOI
https://doi.org/10.1039/D1AN01350E
Article type
Communication
Submitted
27 Jul 2021
Accepted
15 Nov 2021
First published
22 Nov 2021

Analyst, 2021,146, 7386-7393

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On-demand nanozyme signal enhancement at the push of a button for the improved detection of SARS-CoV-2 nucleocapsid protein in serum

D. W. Bradbury, J. T. Trinh, M. J. Ryan, C. M. Cantu, J. Lu, F. D. Nicklen, Y. Du, R. Sun, B. M. Wu and D. T. Kamei, Analyst, 2021, 146, 7386 DOI: 10.1039/D1AN01350E

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