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Using the children's toy, Shrinky-Dink©, we present an aptamer-based electrochemical (E-AB) assay that recognizes the spike protein of SARS-CoV-2 in saliva for viral infection detection. The low-cost electrodes are implementable at population scale and demonstrate detection down to 1 ag mL−1 of the S1 subunit of the spike protein.

Graphical abstract: Detection of the SARS-CoV-2 spike protein in saliva with Shrinky-Dink© electrodes

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