Issue 46, 2021

Spectral imaging of pharmaceutical materials with a compact terahertz difference-frequency generation semiconductor source

Abstract

Spectral imaging of pharmaceutical material using a compact ultra-broadband (1–4 THz) terahertz semiconductor source was demonstrated. False-color RGB images could be obtained using a simple procedure (calibration free). The ability to distinguish the polymorphism of carbamazepine (CBZ), the hydrate forms of D-(+)-glucose and caffeine, and the crystallinity of nifedipine was demonstrated using the THz DFG source. Crystal forms of pharmaceutical materials can be distinguished using this method.

Graphical abstract: Spectral imaging of pharmaceutical materials with a compact terahertz difference-frequency generation semiconductor source

Article information

Article type
Paper
Submitted
01 Oct 2021
Accepted
02 Nov 2021
First published
15 Nov 2021
This article is Open Access
Creative Commons BY license

Anal. Methods, 2021,13, 5549-5554

Spectral imaging of pharmaceutical materials with a compact terahertz difference-frequency generation semiconductor source

A. Nakanishi, K. Akiyama, S. Hayashi, H. Satozono and K. Fujita, Anal. Methods, 2021, 13, 5549 DOI: 10.1039/D1AY01670A

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