Issue 12, 2021
From the journal:

Chemical Communications

Delivery of siRNA by tailored cell-penetrating urea-based foldamers†

Mégane Bornerie, ORCID logo a   Anaïs Brion,b   Gilles Guichard, ORCID logo *a   Antoine Kichler ORCID logo *b  and  Céline Douat ORCID logo *ac  

* Corresponding authors

a Univ. of Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, Pessac F-33607, France
E-mail: g.guichard@iecb.u-bordeaux.fr

b Equipe 3Bio, CAMB 7199 CNRS–Univ., Strasbourg, Faculté de Pharmacie, 74 route du Rhin, Illkirch cedex F-67401, France
E-mail: kichler@unistra.fr

c Department Pharmazie, Ludwig-Maximilians-Universität, Butenandtstraße 5-13, München D-81377, Germany
E-mail: celine.douat@cup.lmu.de

Abstract

Cell-penetrating foldamers (CPFs) have recently shown promise as efficient and safe nucleic acid delivery systems. However, the application of CPFs to siRNA transport remains scarce. Here, we report helical CPFs tailored with specific end-groups (pyridylthio- or n-octyl-ureas) as effective molecular systems in combination with helper lipids to intracellularly deliver biologically-relevant siRNA.

Graphical abstract: Delivery of siRNA by tailored cell-penetrating urea-based foldamers

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Article information

DOI
https://doi.org/10.1039/D0CC06285E
Article type
Communication
Submitted
17 Sep 2020
Accepted
18 Dec 2020
First published
21 Dec 2020

Chem. Commun., 2021,57, 1458-1461

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Delivery of siRNA by tailored cell-penetrating urea-based foldamers

M. Bornerie, A. Brion, G. Guichard, A. Kichler and C. Douat, Chem. Commun., 2021, 57, 1458 DOI: 10.1039/D0CC06285E

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