Issue 4, 2021
From the journal:

Chemical Communications

Cyclopentane FIT-PNAs: bright RNA sensors†

Odelia Tepper,*a   Hongchao Zheng,b   Daniel H. Appella ORCID logo *b  and  Eylon Yavin ORCID logo *a  

* Corresponding authors

a The Institute for Drug Research, The School of Pharmacy, The Hebrew University of Jerusalem, Hadassah Ein-Kerem, Jerusalem 91120, Israel
E-mail: eylony@ekmd.huji.ac.il

b Synthetic Bioactive Molecules Section, Laboratory of Bioorganic Chemistry (LBC), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, 8 Center Drive, Room 404, Bethesda, Maryland 20892, USA
E-mail: appellad@niddk.nih.gov

Abstract

Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine–pyrimidine single nucleotide variants (SNVs).

Graphical abstract: Cyclopentane FIT-PNAs: bright RNA sensors

About
Cited by
Related
Download options Please wait...

Associated articles

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0CC07400D
Article type
Communication
Submitted
10 Nov 2020
Accepted
10 Dec 2020
First published
18 Dec 2020

Chem. Commun., 2021,57, 540-543

Permissions

Request permissions

Cyclopentane FIT-PNAs: bright RNA sensors

O. Tepper, H. Zheng, D. H. Appella and E. Yavin, Chem. Commun., 2021, 57, 540 DOI: 10.1039/D0CC07400D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements