Issue 18, 2021
From the journal:

Chemical Communications

A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer†

Jing Zhang,a   Ningning Wang,a   Qian Li,a   Yaxin Zhoua  and  Yuxia Luan ORCID logo *a  

* Corresponding authors

a Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
E-mail: yuxialuan@sdu.edu.cn

Abstract

A two-pronged concept combining photodynamic therapy (PDT) and epithelial–mesenchymal transition (EMT) blockade in a minimalist nanoplatform was proposed to combat basal-like breast cancer (BLBC) metastasis. Based on PDT-mediated tumor killing and epalrestat (Epa)-mediated EMT blockade, as-prepared Ce6/Epa nanoparticles prevented BLBC metastasis effectively in vivo, providing a very promising two-pronged strategy against BLBC metastasis.

Graphical abstract: A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer

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Article information

DOI
https://doi.org/10.1039/D0CC08162K
Article type
Communication
Submitted
16 Dec 2020
Accepted
21 Jan 2021
First published
22 Jan 2021

Chem. Commun., 2021,57, 2305-2308

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A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer

J. Zhang, N. Wang, Q. Li, Y. Zhou and Y. Luan, Chem. Commun., 2021, 57, 2305 DOI: 10.1039/D0CC08162K

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