Issue 18, 2021
From the journal:

Chemical Communications

Two-photon excited peptide nanodrugs for precise photodynamic therapy†

Hongqian Cao,‡ab   Yanfei Qi, ORCID logo ‡c   Xibao Gao,‡a   Zi Jin Wei,b   Jiarui Xia,d   Lei Wang, ORCID logo b   Hao Wang, ORCID logo b   Yang Yang ORCID logo *b  and  Junbai Li ORCID logo *d  

* Corresponding authors

a School of Public Health, Shandong University, Jinan, Shandong, China

b CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
E-mail: yangyang@nanoctr.cn

c School of Public Health, Jilin University, Changchun, Jilin, China

d CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
E-mail: jbli@iccas.ac.cn

Abstract

A novel peptide nanodrug composed of three functional motifs, bis(pyrene), FFVLK and CREKA, was used as a two-photon excited photosensitizer for precise photodynamic therapy (PDT). The system presented excellent two-photon imaging ability, tumor target effect and high reactive oxygen species productivity for improving treatment precision and efficiency in PDT.

Graphical abstract: Two-photon excited peptide nanodrugs for precise photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/D0CC08219H
Article type
Communication
Submitted
18 Dec 2020
Accepted
29 Jan 2021
First published
29 Jan 2021

Chem. Commun., 2021,57, 2245-2248

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Two-photon excited peptide nanodrugs for precise photodynamic therapy

H. Cao, Y. Qi, X. Gao, Z. J. Wei, J. Xia, L. Wang, H. Wang, Y. Yang and J. Li, Chem. Commun., 2021, 57, 2245 DOI: 10.1039/D0CC08219H

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