Solid phase synthesis of RNA oligonucleotides which are over 100-nt in length remains challenging due to the complexity of purification of the target strand from failure sequences. This work describes a non-chromatographic strategy that will enable routine solid phase synthesis of long RNA strands.
M. He, X. Wu, S. Mao, P. Haruehanroengra, I. Khan, J. Sheng and M. Royzen, Chem. Commun., 2021, 57, 4263 DOI: 10.1039/D1CC00096A
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