Issue 23, 2021
From the journal:

Chemical Communications

Interfacial cationization to quicken redox-responsive drug release†

Yaxin Zheng, ORCID logo a   Jie Lei,a   Qi Li,a   Xuan Jin,a   Qingyuan Lia  and  Yang Li ORCID logo *b  

* Corresponding authors

a School of Pharmacy, Key Laboratory of Sichuan Province for Specific Structure of Small Molecule Drugs, Chengdu Medical College, Chengdu, China

b Department of Pharmaceutics, College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. China
E-mail: beyond20061330@163.com

Abstract

Interfacial cationization could greatly increase the redox-responsiveness of disulfide bond-linked lipid-drug nanoassemblies (NAs) due to the generation and concentration of ionized thiols at the alkalized NAs’ cationic interface. This strategy could be used to prepare redox-ultrasensitive nanocarriers for efficient intracellular drug delivery.

Graphical abstract: Interfacial cationization to quicken redox-responsive drug release

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Article information

DOI
https://doi.org/10.1039/D1CC00156F
Article type
Communication
Submitted
10 Jan 2021
Accepted
10 Feb 2021
First published
10 Feb 2021

Chem. Commun., 2021,57, 2943-2946

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Interfacial cationization to quicken redox-responsive drug release

Y. Zheng, J. Lei, Q. Li, X. Jin, Q. Li and Y. Li, Chem. Commun., 2021, 57, 2943 DOI: 10.1039/D1CC00156F

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