A mitochondria-targeted near-infrared fluorescent probe for imaging viscosity in living cells and a diabetic mice model

Bochao Chen; Shumei Mao; Yanyan Sun; Liyuan Sun; Ning Ding; Chengde Li; Jin Zhou

doi:10.1039/D1CC01104A

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A mitochondria-targeted near-infrared fluorescent probe for imaging viscosity in living cells and a diabetic mice model†

Bochao Chen,‡^a Shumei Mao,‡^a Yanyan Sun,^a Liyuan Sun,^a Ning Ding,^a Chengde Li*^a and Jin Zhou

*^a

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* Corresponding authors

^a School of Pharmacy, Shandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang, P. R. China
E-mail: lichde@wfmc.edu.cn, zhoujin@wfmc.edu.cn

Abstract

A mitochondria-targeted near-infrared fluorescent probe NIR-V with 700 nm emission was designed to monitor cell viscosity changes with high selectivity and sensitivity, which was applied to detect the intracellular viscosity and image pancreatic tissue in a diabetic mouse model. Probe NIR-V provides an effective way to diagnose viscosity related diseases.

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Article information

DOI: https://doi.org/10.1039/D1CC01104A
Article type: Communication
Submitted: 28 Feb 2021
Accepted: 06 Apr 2021
First published: 13 Apr 2021

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Chem. Commun., 2021,57, 4376-4379

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A mitochondria-targeted near-infrared fluorescent probe for imaging viscosity in living cells and a diabetic mice model

B. Chen, S. Mao, Y. Sun, L. Sun, N. Ding, C. Li and J. Zhou, Chem. Commun., 2021, 57, 4376 DOI: 10.1039/D1CC01104A

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Chemical Communications

A mitochondria-targeted near-infrared fluorescent probe for imaging viscosity in living cells and a diabetic mice model†

Abstract

Supplementary files

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A mitochondria-targeted near-infrared fluorescent probe for imaging viscosity in living cells and a diabetic mice model

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