A near-infrared fluorescent probe for accurately diagnosing cancer by sequential detection of cysteine and H+

Zun-Pan She; Wen-Xin Wang; Guo-Jiang Mao; Wen-Li Jiang; Zhi-Qing Wang; Yongfei Li; Chun-Yan Li

doi:10.1039/D1CC01228B

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A near-infrared fluorescent probe for accurately diagnosing cancer by sequential detection of cysteine and H⁺†

Zun-Pan She,^a Wen-Xin Wang,^a Guo-Jiang Mao,^b Wen-Li Jiang,^a Zhi-Qing Wang,^a Yongfei Li

*^ac and Chun-Yan Li

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, P. R. China
E-mail: lichunyan79@sina.com, liyongfei@xtu.edu.cn

^b Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, P. R. China

^c College of Chemical Engineering, Xiangtan University, Xiangtan, P. R. China

Abstract

A near-infrared fluorescent probe, CyAc, is synthesized for accurately diagnosing cancer in vivo by sequential detection of Cys and H⁺. CyAc can not only achieve a good distinction between normal cells and cancer cells, but also distinguish normal mice from tumor mice.

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Article information

DOI: https://doi.org/10.1039/D1CC01228B
Article type: Communication
Submitted: 06 Mar 2021
Accepted: 06 Apr 2021
First published: 06 Apr 2021

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Chem. Commun., 2021,57, 4811-4814

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A near-infrared fluorescent probe for accurately diagnosing cancer by sequential detection of cysteine and H⁺

Z. She, W. Wang, G. Mao, W. Jiang, Z. Wang, Y. Li and C. Li, Chem. Commun., 2021, 57, 4811 DOI: 10.1039/D1CC01228B

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Chemical Communications