Issue 47, 2021
From the journal:

Chemical Communications

An alginate-confined peroxygenase-CLEA for styrene epoxidation†

Friederike E. H. Nintzel, ORCID logo ‡a   Yinqi Wu, ORCID logo ‡a   Matteo Planchestainer, ORCID logo b   Martin Held,b   Miguel Alcaldec  and  Frank Hollmann ORCID logo *a  

* Corresponding authors

a Department of Biotechnology, Delft University of Technology, van der Maasweg 9, Delft, The Netherlands
E-mail: f.hollmann@tudelft.nl

b Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, Basel 4058, Switzerland

c Department of Biocatalysis, Institute of Catalysis and Petrochemistry (CSIC), Madrid, Spain

Abstract

Oxyfunctionalisation reactions in neat substrate still pose a challenge for biocatalysis. Here, we report an alginate-confined peroxygenase-CLEA to catalyse the enantioselective epoxidation of cis-β-methylstyrene in a solvent-free reaction system achieving turnover numbers of 96 000 for the biocatalyst and epoxide concentrations of 48 mM.

Graphical abstract: An alginate-confined peroxygenase-CLEA for styrene epoxidation

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Article information

DOI
https://doi.org/10.1039/D1CC01868J
Article type
Communication
Submitted
08 Apr 2021
Accepted
07 May 2021
First published
07 May 2021
This article is Open Access
Creative Commons BY license

Chem. Commun., 2021,57, 5766-5769

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An alginate-confined peroxygenase-CLEA for styrene epoxidation

F. E. H. Nintzel, Y. Wu, M. Planchestainer, M. Held, M. Alcalde and F. Hollmann, Chem. Commun., 2021, 57, 5766 DOI: 10.1039/D1CC01868J

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