Increasing membrane permeability of carboxylic acid-containing drugs using synthetic transmembrane anion transporters

Abstract

In this manuscript, we show that small-molecule-based anion transporters can significantly increase the permeability of carboxylic acid containing drugs across lipid bilayers of model vesicles. Due to the drug-like characteristics of the transporters, this finding could not only have implications for drug delivery, but also hints towards potential drug–drug and drug–food interactions.