Sodium silylsilanolate enables nickel-catalysed silylation of aryl chlorides

Abstract

Structurally diverse aryl chlorides were silylated with sodium silylsilanolate reagents in the presence of a Ni(cod)₂ catalyst complexed with a phosphine ligand; PMe₂Ph for electron-rich substrates, and PCy₂Ph for electron-deficient ones. The mild reaction conditions allowed the silylation of various aryl chlorides including functionalised drug molecules.