A Mn-catalyzed remote C(sp3)–H bond peroxidation triggered by radical trifluoromethylation of unactivated alkenes

Abstract

A manganese-catalyzed radical relay strategy for the remote trifluoromethylation–peroxidation of unactivated alkenes is disclosed. The electrophilic CF₃ group was added to the CC double bonds to afford remote C-centered radicals upon 1,5-HAT, which could be efficiently trapped by Mnⁿ⁺¹OOBu-t species to deliver 1,6-difunctionalized products selectively under mild conditions. t-BuOOH serves as both the oxidant and the peroxy precursor in this transformation.