Issue 93, 2021
From the journal:

Chemical Communications

Characterizing the spatial distribution of dipeptides in rodent tissue using MALDI MS imaging with on-tissue derivatization†

Kening Li,‡a   Shuai Guo,‡b   Weiwei Tang*a  and  Bin Li ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Natural Medicines and School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China
E-mail: weiweitang@cpu.edu.cn, binli@cpu.edu.cn

b School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China

Abstract

A highly efficient on-tissue derivatization method for the matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) of dipeptides in tissues has been developed via a combination of a home-built laser-assisted chemical transfer (LACT) technique and hexafluoroisopropanol (HFIP).

Graphical abstract: Characterizing the spatial distribution of dipeptides in rodent tissue using MALDI MS imaging with on-tissue derivatization

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Article information

DOI
https://doi.org/10.1039/D1CC05026E
Article type
Communication
Submitted
08 Sep 2021
Accepted
31 Oct 2021
First published
10 Nov 2021

Chem. Commun., 2021,57, 12460-12463

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Characterizing the spatial distribution of dipeptides in rodent tissue using MALDI MS imaging with on-tissue derivatization

K. Li, S. Guo, W. Tang and B. Li, Chem. Commun., 2021, 57, 12460 DOI: 10.1039/D1CC05026E

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