Selective excitation of hydrogen doubles the yield and improves the robustness of parahydrogen-induced polarization of low-γ nuclei

Andreas B. Schmidt; Arne Brahms; Frowin Ellermann; Stephan Knecht; Stephan Berner; Jürgen Hennig; Dominik von Elverfeldt; Rainer Herges; Jan-Bernd Hövener; Andrey N. Pravdivtsev

doi:10.1039/D1CP04153C

Selective excitation of hydrogen doubles the yield and improves the robustness of parahydrogen-induced polarization of low-γ nuclei†

Andreas B. Schmidt,

‡*^abc Arne Brahms,

‡^d Frowin Ellermann,

^c Stephan Knecht,^e Stephan Berner,

^a Jürgen Hennig,

^a Dominik von Elverfeldt,

^a Rainer Herges,

^d Jan-Bernd Hövener

^c and Andrey N. Pravdivtsev

*^c

Author affiliations

* Corresponding authors

^a Department of Radiology, Medical Physics, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Killianstr. 5a, Freiburg 79106, Germany
E-mail: andreas.schmidt@uniklinik-freiburg.de, andrey.pravdivtsev@rad.uni-kiel.de

^b German Cancer Consortium (DKTK), Partner Site Freiburg and German Cancer Research Center (DKFZ), Im Neuen-heimer Feld 280, Heidelberg 69120, Germany

^c Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Kiel, Kiel University, Am Botanischen Garten 14, Kiel, Germany

^d Otto Diels Institute for Organic Chemistry, Kiel University, Otto-Hahn-Platz 5, Kiel, Germany

^e NVision Imagning Technologies GmbH, 89081 Ulm, Germany

Abstract

We describe a new method for pulsed spin order transfer of parahydrogen-induced polarization (PHIP) that enables high polarization in incompletely ²H-labeled molecules by exciting only the desired protons in a frequency-selective manner. This way, the effect of selected J-couplings is suspended. Experimentally 1.25% ¹³C polarization were obtained for 1-¹³C-ethyl pyruvate and 50% pH₂ at 9.4 Tesla.

Physical Chemistry Chemical Physics

Selective excitation of hydrogen doubles the yield and improves the robustness of parahydrogen-induced polarization of low-γ nuclei†

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Selective excitation of hydrogen doubles the yield and improves the robustness of parahydrogen-induced polarization of low-γ nuclei

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