Issue 22, 2021

The not so identical twins: (dis)similarities between reactive electrophile and oxidant sensing and signaling

Abstract

In this tutorial review, we compare and contrast the chemical mechanisms of electrophile/oxidant sensing, and the molecular mechanisms of signal propagation. We critically analyze biological systems in which these different pathways are believed to be manifest and what the data really mean. Finally, we discuss applications of this knowledge to disease treatment and drug development.

Graphical abstract: The not so identical twins: (dis)similarities between reactive electrophile and oxidant sensing and signaling

Article information

Article type
Tutorial Review
Submitted
17 May 2021
First published
20 Aug 2021

Chem. Soc. Rev., 2021,50, 12269-12291

The not so identical twins: (dis)similarities between reactive electrophile and oxidant sensing and signaling

M. J. C. Long, K. Huang and Y. Aye, Chem. Soc. Rev., 2021, 50, 12269 DOI: 10.1039/D1CS00467K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements