A T2ex MRI Dy-based contrast agent for direct pH imaging using a ratiometric approach

Yi Zhang; Kelu Zhao; Haonan He; Sikang Wan; Andre F. Martins; Lei Zhang; Kai Liu

doi:10.1039/D0DT03734F

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A T_2ex MRI Dy-based contrast agent for direct pH imaging using a ratiometric approach†

Yi Zhang,^ab Kelu Zhao,^ab Haonan He,^ab Sikang Wan,^ab Andre F. Martins,

^cd Lei Zhang

*^a and Kai Liu

*^ab

Author affiliations

* Corresponding authors

^a State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
E-mail: kai.Liu@ciac.ac.cn, lei.zhang@ciac.ac.cn

^b University of Science and Technology of China, Hefei 230026, China

^c Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen 72076, Germany

^d Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, University of Tuebingen, Germany

Abstract

pH is a critical parameter that has found unique application in magnetic resonance imaging (MRI) mapping acidity in tissues. This study reports a series of Dy-based MR probes that show innovative T_2ex features, governed by proton catalyzed events. With an increase of pH from 5.5 to 8.0, the r_2ex relaxivity increased dramatically, while the r₁ relaxivity remained unchanged. The resulting r_2ex/r₁ allowed for concentration-independent and direct mapping of physiologically relevant pH ranges.

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Article information

DOI: https://doi.org/10.1039/D0DT03734F
Article type: Communication
Submitted: 30 Oct 2020
Accepted: 18 Jan 2021
First published: 19 Jan 2021

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Dalton Trans., 2021,50, 2014-2017

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A T_2ex MRI Dy-based contrast agent for direct pH imaging using a ratiometric approach

Y. Zhang, K. Zhao, H. He, S. Wan, A. F. Martins, L. Zhang and K. Liu, Dalton Trans., 2021, 50, 2014 DOI: 10.1039/D0DT03734F

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Dalton Transactions