Issue 23, 2021

Point-of-care diagnostics: recent developments in a pandemic age

Abstract

In this review, we provide an overview of developments in point-of-care (POC) diagnostics during the COVID-19 pandemic. We review these advances within the framework of a holistic POC ecosystem, focusing on points of interest – both technological and non-technological – to POC researchers and test developers. Technologically, we review design choices in assay chemistry, microfluidics, and instrumentation towards nucleic acid and protein detection for severe acute respiratory coronavirus 2 (SARS-CoV-2), and away from the lab bench, developments that supported the unprecedented rapid development, scale up, and deployment of POC devices. We describe common features in the POC technologies that obtained Emergency Use Authorization (EUA) for nucleic acid, antigen, and antibody tests, and how these tests fit into four distinct POC use cases. We conclude with implications for future pandemics, infectious disease monitoring, and digital health.

Graphical abstract: Point-of-care diagnostics: recent developments in a pandemic age

Supplementary files

Article information

Article type
Critical Review
Submitted
16 Jul 2021
Accepted
31 Oct 2021
First published
15 Nov 2021

Lab Chip, 2021,21, 4517-4548

Author version available

Point-of-care diagnostics: recent developments in a pandemic age

H. Harpaldas, S. Arumugam, C. Campillo Rodriguez, B. A. Kumar, V. Shi and S. K. Sia, Lab Chip, 2021, 21, 4517 DOI: 10.1039/D1LC00627D

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