Sulfonyl radical-induced regioselective cyclization of 3-aza-1,5-enynes with sulfonyl chlorides to produce 1,2-dihydropyridines by copper catalysis

Abstract

A Cu-catalyzed regioselective cyclization of 3-aza-1,5-enynes with sulfonyl chlorides for the synthesis of 1,2-dihydropyridines is described. This present method provided a new pathway for the construction of 1,2-dihydropyridines from 3-aza-1,5-enynes in reasonable yields and an alternative method for the synthesis of 3-functionalized multi-substituted pyridines.