Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection

James J. Hobson; Alison C. Savage; Andrew B. Dwyer; Catherine Unsworth; Jonathan Massam; Usman Arshad; Henry Pertinez; Helen Box; Lee Tatham; Rajith K. R. Rajoli; Megan Neary; Joanne Sharp; Anthony Valentijn; Christopher David; Paul Curley; Neill J. Liptrott; Tom O. McDonald; Andrew Owen; Steve P. Rannard

doi:10.1039/D1NR00309G

Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection†

James J. Hobson,

^ab Alison C. Savage,

^ab Andrew B. Dwyer,^ab Catherine Unsworth,

^ab Jonathan Massam,^ab Usman Arshad,^bc Henry Pertinez,^bc Helen Box,^bc Lee Tatham,^bc Rajith K. R. Rajoli,^bc Megan Neary,^bc Joanne Sharp,^bc Anthony Valentijn,^bc Christopher David,^bc Paul Curley,^bc Neill J. Liptrott,

^bc Tom O. McDonald,

^ab Andrew Owen*^bcd and Steve P. Rannard

*^abd

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Liverpool, Crown Street, UK
E-mail: srannard@liverpool.ac.uk

^b Centre of Excellence in Long-acting Therapeutics (CELT), University of Liverpool, Liverpool, UK

^c Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK

^d Materials Innovation Factory, University of Liverpool, Crown Street, UK

Abstract

The control of COVID-19 across the world requires the formation of a range of interventions including vaccines to elicit an immune response and immunomodulatory or antiviral therapeutics. Here, we demonstrate the nanoparticle formulation of a highly insoluble drug compound, niclosamide, with known anti SARS-CoV-2 activity as a cheap and scalable long-acting injectable antiviral candidate.

This article is part of the themed collection: Nanoscale Most Popular 2021 Articles

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Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection†

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Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection

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