Rapidly clearable MnCo2O4@PAA as novel nanotheranostic agents for T1/T2 bimodal MRI imaging-guided photothermal therapy

Abstract

Integrating multi-modal imaging and therapy functions into a nanoplatform has been recognized as a promising strategy for cancer theranostics with high accuracy and efficiency. However, there are still some challenges, such as the complicated synthesis process and instability. Herein, we successfully prepared clearable MnCo₂O₄ nanodots modified with polyacrylic acid (MnCo₂O₄@PAA) as nanoagents for T₁/T₂ bimodal MRI imaging-guided PTT. Owing to their intrinsic magnetic properties, single MnCo₂O₄@PAA nanomaterials can serve as contrasts for T₁/T₂ bimodal MRI, providing precise diagnotic information. Moreover, excellent absorption in the NIR biowindow endows MnCo₂O₄@PAA with good photothermal performance, and the ultrasmall size of MnCo₂O₄@PAA allows them to penetrate deeply into tumors, resulting in a good anticancer effect in vitro and in vivo. What is more, MnCo₂O₄@PAA can almost be completely cleared from mice at 7 d postinjection, implying their negligible long-term toxicity. These findings demonstrate that MnCo₂O₄@PAA are promising nanoagents for cancer diagnosis and treatment, which have great potential for clinical applications.