Issue 12, 2021

Metal-free multicomponent reactions: a benign access to monocyclic six-membered N-heterocycles

Abstract

The advent of multicomponent reactions in the synthesis of heterocycles and their ever burgeoning applications in drug development, materials chemistry, and catalysis, have attracted a great deal of current scientific interest. In particular, the metal-free multicomponent synthesis of six membered N-heterocycles has undergone intensive research over the last two decades offering an environmentally benevolent means contrary to traditional metal catalysed reactions. To the best of our knowledge, there exists no exclusive review on the metal-free multicomponent synthesis of six membered N-heterocyles, and hence the present report highlights the progress on metal-free multicomponent reactions with their advantages and mechanistic insights to access monocyclic six-membered N-heterocycles including pyridine, pyrimidine, pyrazine, triazine and their hydrogenated derivatives. The literature is covered since 2000, and the contents offer not only striking methods for divergent synthesis of six-membered N-heterocycles but also put forward some new insights into the exploration of metal-free multicomponent chemistry.

Graphical abstract: Metal-free multicomponent reactions: a benign access to monocyclic six-membered N-heterocycles

Article information

Article type
Review Article
Submitted
25 Jan 2021
Accepted
19 Feb 2021
First published
22 Feb 2021

Org. Biomol. Chem., 2021,19, 2622-2657

Metal-free multicomponent reactions: a benign access to monocyclic six-membered N-heterocycles

Preeti and K. N. Singh, Org. Biomol. Chem., 2021, 19, 2622 DOI: 10.1039/D1OB00145K

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