Preparation of hexafluoroisopropyl esters by oxidative esterification of aldehydes using sodium persulfate

Abstract

A simple, metal-free route for the oxidative esterification of aldehydes to yield hexafluoroisopropyl esters is reported. The methodology employs sodium persulfate and a catalytic quantity of a nitroxide and is applicable to aromatic, heteroaromatic, and aliphatic aldehydes.